Effect of L-carnitine supplementation on the sGC/cGMP pathway in vascular relaxing responses from exercised rats
نویسندگان
چکیده
Background It has been largely documented the beneficial effects of physical training on the endothelium-derived relaxing response by increasing nitric oxide production and/or its bioavailability to the smooth muscle [1]. L-carnitine (LCar) has been used as important supplement to regulate body composition associated with lipid metabolism. However, no studies exist investigating the effect of L-Car intake associated with dynamic exercise on the NO-independent sGC/cGMP pathway in the vascular responsiveness in rats. Thus, the aim of this work was to investigate the effect of L-Car supplementation on the NO-independent sGC/cGMP pathway in aortic and mesenteric rings in trained rats.
منابع مشابه
L-arginine supplementation improves aortic vascular relaxation via NO-independent sGC/cGMP signaling in exercised rats
Background It is well established that physical training promotes beneficial effects on the vascular reactivity by improving the NO/cGMP signaling pathway [1]. L-Arginine (L-Arg) is a non-essential amino acid which plays a critical role in many organism functions such as pH regulation and endothelial cell membrane depolarization. Moreover, the benefits of the oral supplemention with L-Arg have ...
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